Use the station name
Venice Santa Lucia and Venice Mestre are not the same arrival point.
Join the cities by rail. Decide where to sleep before turning every place on the line into another hotel change.

A north-to-south sequence of rail-linked cities, not a timetable. Select a base to see what it adds.
Venice belongs to the northern part of this rail plan. Santa Lucia station is in the lagoon city; compare that arrival with accommodation on the mainland before choosing where to stay.
The sequence shows planning order, not a single train or guaranteed service. Check the station, date and fare conditions with the operator.
Choose two strong bases before adding a third. Our Italy planning guide helps you count usable days, compare route shapes and identify the rail and admission bookings worth fixing first. Use the city choices above for orientation, then make a night-by-night plan before paying for transfers.
Plan your Italy tripVenice Santa Lucia and Venice Mestre are not the same arrival point.
A connection on a rail network does not mean each city needs an overnight stop.
A regional town, trail or countryside stay may need another connection after the high-speed train.